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11 However, some people may experience vitamin B12 side effects when taking high doses of supplements

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In a 2006 randomized, placebo-controlled, double-blind escalating-amount trial of CJC-1295 in healthy adults published in the Journal of Clinical Endocrinology & Metabolism , single subcutaneous amounts produced concentration-dependent increases of approximately 2- to 10-fold in mean GH concentrations and 1.5- to 3-fold in IGF-1 concentrations, with effects on the GH/IGF-1 axis lasting between 6 and 14 days [1]

In the US, however, most physicians give vitamin B12 injections